97 MULTIMODAL EVALUATION OF MYOCARDIAL FIBROSIS IN PATIENTS WITH AORTIC STENOSIS

Abstract Introduction Patients with aortic stenosis often develop hypertrophy and fibrosis, regardless of symptoms. Cardiac magnetic resonance (CMR) represents the gold standard for evaluation fibrosis despite numerous limitations: cost, availability, atrial fibrillation, claustrophobia, kidney failure or inability to apnea. Aim The aim is validate role echocardiographic parameters, such as Global Longitudinal Strain (GLS), early marker fibrosis. Clinical laboratory data, particularly BNP, were also analyzed. Material Methods In our study we recruited 33 patients severe stenosis, comparing values GLS those Late Gadolinium Enhancement (LGE) T1 mapping CMR. Results 70% an alteration had LGE+. Univariate logistic regression shows that factors associated presence LGE on CMR are hypertension (p = 0.043), 0.032) elevated Pro-BNP 0.021); GLS, odds ratio (OR) 5 so chance finding increases times in altered GLS. multivariate analysis confirms association impaired 0.033 =) 0.025), but not values. Conclusions between can help identify earlier structural changes caused by disease, who could benefit from intervention. It remains be established, through a longer follow-up, how these alterations influence outcome suffering stenosis.